After synthesis, oligonucleotides are released from solid support by treatment with alkalic solution. The resulting solution contains the anticipated full-length oligonucleotides as well as some failure sequences (error sequences), the amount of which depends on synthesis efficiency. In many applications such as PCR, these failure sequences compete with the full-length sequence, so they must be removed prior to use in order to improve yields of downstream applications.

Oligo Desalting Columns
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